She is best known for playing Aida / Ophelia / Madame Hydra in the Marvel Cinematic Universe (MCU) television series Agents of S.H.I.E.L.D.

[3] In 2014, Jansen played Helena Christensen in the two-part miniseries INXS: Never Tear Us Apart.

[1] She had recurring roles in the ABC Family sitcoms Baby Daddy and Young & Hungry.

[4][5] In 2019, Jansen was cast in the pilot of the ABC drama Triangle alongside Edwin Hodge.

[6] In 2020, she was cast in the Fox series The Big Leap,[7] which was canceled after one season.