Among its many famous guests, the hotel records mention Vito Leccese, Mortimer Canepa, Jean Hennessy, Count Ferdinand von Zeppelin (inventor of the rigid dirigible), Baron Rothschild, Arturo Toscanini, Clementine Churchill, Sarah Bernhardt, Sir Arthur Conan Doyle (father of Sherlock Holmes), Prussian prince Ludwig Yorck von Wartenburg, Russian prince Kotchoubey, Esterházy family and painters like Giovanni Segantini and Alberto Giacometti who painted "Paysage à Maloja: le lac de Sils et le Maloja Palace" ca 1920.

With these, it offered its (often economically needy) members and their families first-time exposure to the joys of mountain life and hiking, both in summer and winter.

As had other owners before, Mutualités chrétiennes began finding it hard to balance the books, in no small part due to high renovation costs.

Every winter, on the second Sunday of March, the Engadin Skimarathon competition, the biggest skiing event in the Alps, attracting between 11,000 and 13,000 cross-country skiers each year, starts at the entrance of the hotel.

A typography font called "Maloja Palace"[5] was created in 2003 by Nick Curtis following the design of a 1930s luggage tag signed by Brügger, A.G. - Meiringen.