A flash sync terminal is part of the lens unit, and the delay can be set to M or X mode.

[1]: 26  The C2 was introduced in June 1958 and is distinguished from its predecessor with a second focusing knob on the left side of the camera.

[1]: 26 The "Mamiyaflex" name was dropped for "Mamiya" when the C3 was introduced in February 1962; the C3 featured updated styling, adding the name above the lens mount and switching to a gray leather body covering.

[1]: 26–27  The main distinguishing feature was the C33 had more automated operation, where winding the film also cocked the shutter automatically;[3] the C22 required two separate actions.

[1]: 26–27 The C220 (April 1968) and C330 (October 1969) models were developed from the C22 and C33, respectively, with updated styling (the prominent nameplate now had chrome lettering on black) and a built-in switchable pressure plate to enable the use of 220 film.

[5][6] The later C330f, C220f, and C330S were refined versions of their respective base cameras, and carried the letter annotation on a nameplate below the lens mount.

The Mamiya C series were marketed as system cameras, and over time a wide array of accessories were offered.