Their investigation takes them to a town overrun by werewolves controlled by Dredmund the Druid, where Captain America skirmishes with the werewolf-hunting Moonhunter and a brainwashed Wolverine.

"Capwolf" finds that he has been captured alongside superheroes with werewolf-like powers, such as Jameson, Wolfsbane, and Werewolf By Night, and leads them to defeat Nightshade.

[4] The conclusion to "Man and Wolf", which sees Captain America fight his doppelganger, ties the story into the 1992 crossover series The Infinity War.

[1] Chris Sims of Comics Alliance described "Man and Wolf" as the "most famous oddity of Gruenwald's tenure" on Captain America and noted its reputation as "one of the most bizarre moments of the core Marvel Universe", but commended it as a "highly enjoyable, insanely over-the-top story".

[8] A 2022 storyline in Captain America: Symbol of Truth in which Joaquin Torres (Falcon) is transformed into a life-sized bird was noted by critics as reminiscent of "Man and Wolf".