[1][2] He published a medical textbook, the Keitekishū (啓迪集), in 1571, and worked as a doctor for many daimyō of the time.
When Monotari visited him the following year, Dōsan presented him with nine rules for health, known as the Kyuki.
These were:[2] That same year, he also visited Matsunaga Danjō Hisahide, where he lectured on Chinese texts on sex and the nurturing of life.
[1] He and his heirs (both natural and adopted) were instrumental in the spread of the Goseihō school of medical thought in Japan, which stemmed from Chinese systems of medicine.
[4] In the light novel Honnōji kara Hajimeru Nobunaga to no Tenka Tōitsu series, when Makoto suddenly developed a high fever from excessive exhaustion, Manase Dosan was immediately summoned by Oda Nobunaga to treat him and saved his life.