Joshi started playing badminton when she was six along with her father, a retired scientist from Bhabha Atomic Research Centre.

[12] In September 2015, Joshi won a silver medal in mixed doubles at the Para-Badminton World Championship held in Stoke Mandeville, England.

[13][14] In October 2018, she won a bronze medal for India at the Asian Para Games 2018, held in Jakarta, Indonesia.

[7][15] She won a silver medal in the doubles along with Thulasimathi Murugesan and a bronze in the singles SL3 in the 2022 Asian Para Games at Gangzhou, China.

[16][17] Manasi was listed as the Next Generation Leader 2020 by TIME Magazine in October 2020 and she appeared on their Asia cover, making her the first para-athlete in the world and the first Indian athlete to be featured on the magazine's cover, for being an advocate of rights for people with disabilities.