It was the fourth permanent settlement established in the Northwest Territory.

In 1933, Alfred Holbrook College moved to Manchester where it closed in 1941.

Manchester is the approximate halfway point between Cincinnati and Huntington, West Virginia.

As of the census[9] of 2010, 2,023 people, 818 households, and 527 families resided in the village.

There were 1,032 housing units at an average density of 806.3 per square mile (311.3/km2).

30.3% of all households were made up of individuals, and 14.1% had someone living alone who was 65 years of age or older.

33.3% of all households were made up of individuals, and 18.8% had someone living alone who was 65 years of age or older.

About 19.1% of families and 23.3% of the population were below the poverty line, including 29.7% of those under the age of 18 and 23.3% of those 65 and older.