The high school became accredited in 1924, graduating 3 students that year.

The International Baccalaureate (IB) Program has been a specialty center at Midlothian High School since 2001.

This program is one of the fourteen specialty centers in Chesterfield County.

If accepted into the program, students are placed in honors/AP classes during their freshman and sophomore years in preparation for the more rigorous IB classes they will take in their junior and senior years.

[4] In 2017, parents of students at Midlothian High School received an email from the principal after an "inappropriate image" was shown during a presentation.