Manciano is a town and comune in the southern part of the province of Grosseto, Tuscany, central Italy.

Manciano was once a fairly important market town for the area of the Albegna and Fiora valleys, with a stronghold already recorded in the twelfth century.

The comune is further known to students of Late Antiquity as the place where the famous silver platter of Ardabur Aspar, consul in 434, was found (in the Fosso Castione, a creek near Marsiliana).

The densely built town centre of the frazione Montemerano, crowned by its leaning tower of San Lorenzo, is contained within its ancient walls.

The thirteenth-century church is dedicated to San Lorenzo; frescoes remain on its walls, and a polyptych by the Sienese painter Sano di Pietro.