Mandello del Lario (Lecchese: Mandèll) is an Italian town and comune in the province of Lecco, in Lombardy, on Lake Como.

Since 1921, Mandello del Lario has been home to Moto Guzzi—the Italian motorcycle manufacturer, now a subsidiary of Piaggio & Co. SpA.

The Grigna massif is located in Mandello's communal territory.

[4] A holy-water font decorated with a geometrical twisting floral motif (very popular in the Como area between the 6th and 11th century) on the font and with a relief (not very prominent) showing a cross on the sides, is preserved from the original building.

In the nave are numerous votive frescoes dating back to the 15th century; the Crucifixion in the presbytery is from the end of the 15th century; the eschatological cycle, according to some researchers, is related to the Ligurian-Piedmontese painting tradition, whilst according to others it is closer to the local tradition, and is placed around 1480.