It stars David Marsais, Grégoire Ludig, Adèle Exarchopoulos, India Hair, Roméo Elvis, Coralie Russier, Bruno Lochet, and Dave Chapman.

[4] Jean-Gab and Manu, two simple-minded friends, find a giant fly stuck in the trunk of a car and set themselves up to train it to earn money with it.

In September 2019, it was announced David Marsais, Grégoire Ludig, Adèle Exarchopoulos, India Hair, Roméo Elvis and Coralie Russier had joined the cast of the film, with Quentin Dupieux directing from a screenplay he wrote.

The website's critics consensus reads, "Mandibles finds writer-director Quentin Dupieux off on another thoroughly original flight of fancy that will captivate like-minded audiences while baffling others.

"[11] During an interview in the French magazine CinemaTeaser on 24 May 2021, Dupieux hinted that he was ready to make a sequel if the film exceeded 500,000 admissions in France.