Two generations of the Manfredini family of painters were active in Cremona during the 18th and 19th centuries.
He worked in the hall of canenichesse of San Benedetto, and painted for the salons in the houses of the Magio and Gerenzani family His major work in Cremona was painting the interior of the church of San Faccio, also called Il Foppone.
The oldest, Paolo Manfredini, (1754-November 25, 1805) had modest talents.
The youngest brother, Serafino Manfredini, showed the most talent.
He painted extensively in the Cathedral of Cremona: in 1823, he decorated the chapel of the Blessed Virgen del popolo; in 1825, the chapel of the Blessed Sacrament; and in 1826, he repainted the altarpiece of Annunziata, originally by Malosso.