- biochemical blood test: determination of the activity of ALT, ACT, LDH, creatine phosphokinase (CPK); - indicators of protein metabolism, - concentrations of thyroid hormones.Instrumental research.

[3] In initial stages of manganism, neurological symptoms consist of reduced response speed, irritability, mood changes, and compulsive behaviors.

Manganism has become an active issue in workplace safety as it has been the subject of numerous product liability lawsuits against manufacturers of arc welding supplies.

[24][25] It participates in Fenton reactions and could thus induce oxidative damage, a hypothesis corroborated by the evidence from studies of affected welders.

Pregnant animals repeatedly receiving high doses of manganese bore malformed offspring significantly more often compared to controls.

[33] Enhanced excretion of manganese prompted by chelation therapy brings its blood levels down but the symptoms remain largely unchanged, raising questions about efficacy of this form of treatment.

[34][35] Increased ferroportin protein expression in human embryonic kidney (HEK293) cells is associated with decreased intracellular manganese concentration and attenuated cytotoxicity, characterized by the reversal of manganese-reduced glutamate uptake and diminished lactate dehydrogenase (LDH) leakage.