[1] Some of the enterprises residing in the building include: Telemundo, Macy's, CFDA, WeWork, Facebook, iHeart Media, Samsung, American Heart Association, Robin Hood, FX Network, Endeavor, MAC Cosmetics, Viacom, SiriusXM, NBA, NBC Universal, Masterbeat, Formerly Al Jazeera America HQ, Broadway Cares Equity Fights AIDS.

Rapidly, it received critical acclaim[3] and became a popular alternative to the Met, and many great operas and celebrated singers debuted at the new theater.

In March 1911, it was opened as a "combination" house by the Shubert brothers featuring vaudeville shows during the week and concerts on Sunday nights at affordable prices.

In 1922, the Manhattan Opera House was purchased by the Ancient Accepted Scottish Rite of Free Masonry, who built a new building façade and a new Grand Ballroom on the seventh floor.

In 1926, Warner Bros rented the ballroom to set up a studio for the Vitaphone sound-on-disc system to record the New York Philharmonic orchestra for the film Don Juan.

The Manhattan Center became a hot spot for "big band" dances as well as trade shows, union meetings and other social functions.