Three of the serial's cliffhanger gags and set pieces are copied in Indiana Jones and the Temple of Doom.

A breakthrough scientific device will revolutionize the world's energy usage if the kidnapped creator can be found.

Clues lead them to a remote Pacific isle known only as Mystery Island, where the two confront sinister and astonishing forces.

Worst of all, one of the heirs possesses a Transformation Machine with the impossible ability of changing him into the molecular duplicate of his ancestor, Mephisto.

[1] Manhunt of Mystery Island was one of twenty-six Republic serials re-released as a "Century 66" film on television in 1966.