The James Brothers of Missouri is a 1949 American Republic Western film serial.

The James Brothers of Missouri was budgeted at $164,986 although the final negative cost was $164,757 (a $229, or 0.1%, under spend).

[1] Special effects were created by the Lydecker brothers.

The James Brothers of Missouri's official release date is 31 August 1949, although this is actually the date the sixth chapter was made available to film exchanges.

[1] William C. Cline, author of In the Nick of Time: Motion Picture Sound Serials, dismisses this serial as a "quick warm-over" of the first two Jesse James serials.