Manifesto released the entire catalogue of Dead Kennedys in 2001 after the band obtained the rights from Alternative Tentacles.
In November 2015, Manifesto re-released the entire catalogue of Lee Michaels that had been on A&M Records.
Manifesto is headed by Evan Cohen, a music-business and copyright lawyer and nephew of Herb Cohen, the late former manager of Frank Zappa, Tim Buckley, Linda Ronstadt, and Tom Waits.
In August 2015, the label announced that it was signing several new artists, including Puro Instinct, Drinking Flowers, Cellars, and Band Aparte.
In November 2018, Manifesto released a nine-CD box set of the complete recordings of Kalapana from 1975 to 1983.