It connects the communities of Bruxelles, Notre Dame de Lourdes, Roseisle, and Graysville with the town of Carman.

It enters the Municipality of Lorne and heads due east through rural farmland for several kilometres, crossing the Cypress River and have a junction with PR 532 before travelling through the hamlet of Bruxelles along Main Street, where it goes through a couple of sharp curves and becomes paved.

The highway heads east, travelling past Lake Eleven before becoming concurrent (overlapped) with PTH 34 northbound for roughly 5 kilometres (3.1 mi).

The highway goes through a few curves as it enters the Rural Municipality of Dufferin, travelling through Roseisle (where it has a short concurrency with PR 240) before passing by Stephenfield Provincial Park.

PR 245 winds its way back and forth for the next several kilometres to enter the town of Carman, travelling past neighbourhoods and golf courses as it crosses the Boyne River three more times to enter downtown along 4th Avenue SW, coming to an end at an intersection between PTH 3 and PTH 13 (Main Street S / 4th Avenue SE).