[2] The northern terminus of PTH 13 is located between Portage la Prairie and Manitoba's capital city Winnipeg.

The highway heads straight through the centre of downtown, crossing the Boyne River along a two-lane bridge before temporarily widening back out to a four-lane heading through a neighbourhood as Main Street N. The road narrows to two lanes for the final time at a railroad crossing and passes through a business district before leaving Carman and entering the Rural Municipality of Dufferin.

PTH 13 heads due north, crossing the Norquay Channel and having an intersection with PR 305 in Barnsley before entering the Rural Municipality of Grey.

Shortly thereafter, PTH 13 comes to an end at an intersection with PTH 1 (Trans-Canada Highway / Yellowhead Highway), with the roadway continuing on towards St. Ambroise, St. Ambroise Beach Provincial Park, and Lake Manitoba as PR 430.

[8] On September 12, 2007, the Manitoba government entered to cost share safety improvements at a railway crossing at Highway 13 near Oakville to provide an automated advance warning system.