Provincial Road 435 (PR 435) is a 38.8-kilometre-long (24.1 mi) east–west highway Interlake and Eastman regions of Manitoba.

It connects the town of East Selkirk with Ladywood, the Agassiz Provincial Forest, and the Milner Ridge Correctional Centre.

PR 435 begins in the Rural Municipality of St. Clements just outside the town of East Selkirk at an intersection with PTH 59.

The highway has an intersection with PTH 12 just south of the hamlet of Ladywood before going through a couple of curves as it crosses a bridge over the Brokenhead River.

After traversing a few more kilometres of farmland, PR 435 begins rising slightly in elevation as it enters the woodlands of both the Agassiz Provincial Forest and the Rural Municipality of Lac du Bonnet.