Mannsville is a town in Johnston County, Oklahoma, United States.

0.02 square miles (0.06 km2), or 0.73% of the town's area, are water bodies.

[5] U.S. Route 177 passes through the center of Mannsville, leading west 6 miles (10 km) to the center of Dickson and southeast 10 miles (16 km) to Madill.

Mannsville has an all-volunteer fire department three stations, two in town and one in the small community of Greasy Bend.

25.3% of all households were made up of individuals, and 10.0% had someone living alone who was 65 years of age or older.