Wapanucka (pronounced Wop´-uh-nuck´-uh) is a town in northeastern Johnston County, Oklahoma, United States.

The town name refers to the Delaware Nation and means "Eastern Land People.

"[5] The Board of Foreign Missions of the Presbyterian Church built the Wapanucka Female Manual Labour School in 1851–2.

The school closed in 1860 after the Presbyterian Board withdrew its financial support.

The Confederate forces used the building during the Civil War as a hospital and a prison.

[5] Wapanucka is located 20 miles (32 km) northeast of Tishomingo, the county seat.