After his first expedition into the wilderness in 1769, Mansker explored and hunted widely in the area along the Cumberland River in Middle Tennessee and Kentucky.
Mansker's station was a log fort that protected travelers along the road from Indian attacks.
Because of the danger from the Indian wars, Mansker and the people living there abandoned the station and moved to Fort Nashborough in 1781.
However, Mansker returned to the area in 1783 and built a bigger fort about one mile from the original site where he lived with his wife Elizabeth.
These included Captain William Bowen, General Daniel Smith, Isaac Bledsoe, Andrew Jackson, John Overton and French botanist André Michaux.