[1] Born and raised in São Paulo, she is the daughter of broadcaster and presenter Zé Luiz and psychologist and artist Daniela Gavassi.

[4] Karol Pinheiro, one of Capricho's reporters at the time, found out that Manu was singing and requested the singer's video for him on the magazine's website.

The singles "Garoto Errado" and "Planos Impossíveis" both received gold record by Pro-Música Brasil.

[14][15] In the same month she made her debut as an actress, making a cameo in the series Julie e os Fantasmas as Debora.

[25][26][27] In February, she made her debut in the soap opera Em Familia playing the singer Paulinha.

[31][32][33] Manu was only going to take part in the plot, but due to the success of her character, at the request of the fans, she returned and remained until the end of the series.

[51] With the Fundação Pró-Sangue, as a partnership, the Play For Life campaign aimed to encourage donation from the singer's fans.

[53] In November 2016, she began filming her first movie Socorro, Virei Uma Garota playing the protagonist Melina.

[66] In July she made a cameo appearance in the series Planeta B, which was shown at Multishow, playing serial killer Josephine.

[83][84] In the same month, she launched a life-based web series entitled Garota Errada on her YouTube channel, which was directed and scripted by her.

[91] In December 2019, Gavassi performed at Teatro Net São Paulo, an intimate acoustic show named Cute but Psycho Experience, where she focused on singing songs from her last two EPs.

[92] In 2020, she participated in the twentieth season of the reality show Big Brother Brasil, as one of the guests of the box group, taking 3rd place with 21.09% of the votes.

[93][94] Before joining the program, Manu recorded videos for her web series Garota Errada, which were published through her Instagram, portraying in a funny way her participation in BBB.

[96] In April, it was reported that the Globoplay streaming platform would be interested in producing the series, due to the great success it received.

[97] In interviews, Gavassi revealed that she will turn "Garota Errada" into a series and that there is a possibility for it to go to TV or streaming and have the direction of the actor Selton Mello and the participation of the actress Bruna Marquezine.

[98] On January 28, she released as a single the song "Audio of Excuses", a track that is part of the EP Cute but (still) Psycho, rereleased in September 2019.

[111] In June, Gavassi was invited to join the cast of the soap opera Salve-se Quem Puder, but she had to turn down the invitation, since she was already participating in the cast of the series Maldivas, scripted by the writer Natália Klein, the recordings are scheduled for September and will be shown on Netflix[112][113] On August 21, Gavassi released the new single, "Deve Ser Horrível Dormir Sem Mim" with Gloria Groove.