After completing university, he emigrated to Puerto Rico, then an overseas province of Spain, and quickly became prominent in its business circles.

After the American occupation, Egozcue Cintrón joined the newly formed Republican Party of Puerto Rico, whose main goal was obtaining statehood status for the island.

He served on its board of directors, where he worked closely with party founder José Celso Barbosa.

In 1904 he was again elected mayor, but his term was truncated when territorial governor William Henry Hunt ordered his removal from office after a corruption scandal that tainted much of city government.

Although Egozcue Cintrón was ultimately acquitted of all charges, the ordeal affected him deeply, requiring his internment in a psychiatric hospital.