Manuel Ezequiel Bruzual (Santa Marta, Colombia, 1830 – Curaçao, 15 August 1868), was a military leader committed to liberal ideas.

Later, once the Federalist movement took government, President Juan Crisóstomo Falcón designated him as War and Navy minister (1864), resigning to the position after being imprisoned for the charges of conspiring.

On 6 April 1868, in Güigüe, had an interview with Miguel Antonio Rojas, Head of the Army of the Revolución Azul (Blue Revolution), and agreed the suspension of the hostilities by the lapse of 15 days, in order to discuss a treaty of peace, which was signed on 11 May.

Later, on 19 June, had an interview with José Tadeo Monagas, leader of the Revolución Azul, but did not obtain an agreement, and the Government was overthrown.

Bruzual departed to Puerto Cabello, and thence is proclaimed in exercise of the presidency, he enlists troops, but was defeated by José Ruperto Monagas, on 14 August 1868.