A common theme in his paintings is a collection of still life objects arranged on a shelf against a dark background.
From the late 1990s Franquelo worked and collaborated with Adam Lowe and engineer Sven Nebel.
[3] With the support of Factum Arte and Factum Foundation, Franquelo created the Lucida 3D Scanner, used to record three-dimensional images of low-relief surfaces such as those of paintings and frescoed wall surfaces, and still in use by Factum in 2020.
[4] Franquelo trained as an electronic engineer, and subsequently produced installations and sculptures often incorporating electronics or computer control.
In 2001, Franquelo and Lowe contributed to a project, along with the Egyptian Supreme Council of Antiquities, Ahmad Baghat and Michael Mallinson, to demonstrate that it was possible to laser-scan and replicate the tomb of Seti I in the Valley of the Kings.