Manuel Lobo Antunes GCIH ComM (born 27 June 1958) is a Portuguese diplomat and former politician who serves as the current Permanent Representative of Portugal at the Organisation for Economic Cooperation and Development.

Antunes began his career as a diplomatic adviser to President António Ramalho Eanes in 1984.

In 1988 Antunes left Portugal to take up his first overseas posting as a secretary in the Portuguese Mission to the Hague, before being sent to Harare, Zimbabwe as a councillor.

Upon the election of the government of José Socrates in 2005, Antunes was asked to serve as Secretary of State for National Defence and Sea.

In mid-2006 it was announced that Antunes would move from the Ministry of National Defence to the Portuguese Foreign Affairs Department as Secretary of State for European Affairs, where he oversaw Portugal's presidency of the European Union, and was one of the main negotiators of the final phase of the Treaty of Lisbon.