Moschopoulos was a student of Maximos Planudes and possibly his successor as a head of a school in Constantinople, where he taught throughout his life.
His chief work is Erotemata grammaticalia (Ἐρωτήματα Γραμματικά),[1] in the form of question and answer, based upon an anonymous epitome of grammar, and supplemented by a lexicon of Attic nouns.
His grammatical treatises formed the foundation of the labors of such promoters of classical studies as Manuel Chrysoloras, Theodorus Gaza, Guarini, and Constantine Lascaris.
As an editor, while making many false conjectures, he was responsible for clearing many long-standing errors in the traditional texts.
A selection from his works under the title of Manuelis Moschopuli opuscula grammatica was published by F. N. Titze (Leipzig, 1822); see also Karl Krumbacher, Geschichte der byzantinischen Litteratur (1897) and M. Treu, Maximi monachi Planudis epistulae (1890), p. 208.