Manuel Negrete Arias (born 11 March 1959) is a Mexican former professional footballer and manager, who played as a midfielder.

Negrete became a professional football player in 1980 with Club Universidad Nacional of Mexico, also known as Pumas.

His style of play gave him instant recognition among Mexican soccer fans, with Negrete becoming a household name quickly.

After the 1986 World Cup, Negrete continued playing in the Mexican Football League, and then reached the European soccer leagues by joining Sporting CP in Portugal and then moving to Sporting Gijón in Spain.

At the 1986 FIFA World Cup finals, Negrete participated in five games and scored one goal in the round of 16 against Bulgaria in the 35th minute, the first of a 2–0 win.