[2][3][4] Manuel de Mercado Aldrete was born in Spain and ordained a priest in the Order of Saint Jerome.
[4][5] On February September 4, 1570, Pope Pius V, appointed him Bishop of Puerto Rico.
[2][5] In 1571, he was consecrated bishop by Cristóbal Rojas Sandoval, Archbishop of Seville.
[5] On March 28, 1576, Pope Gregory XIII, appointed him Bishop of Panamá.
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