[5] The high school, one of five to be established in the suburban areas of Greater Houston in 2006,[6] was projected to have 706 students in its first year.

By April 2006, Alvin ISD had hired assistant principals, athletic coaches, a librarian, and a band director for Manvel High.

Phase I, with 220,113 square feet (20,449.2 m2) of space, initially had a capacity of 1,500 students and was built for $52 million.

[20] The Manvel Mavericks compete in these sports - [21] In 2006 Kirk Martin was hired as the assistant athletic director and as the American football coach.

[23] The school adopted a Lakota Sioux-era rallying cry, "Hoka Hey," for use in athletic competitions.

[24] Over the years, multiple MHS students have been lost to car accidents and other events; in their honor, there is a tree and a plaque bearing their names in front of the school.