The district capital is the town of Manyoni.

The district is bordered to the north by the Ikungi District, to the east by the Dodoma Region, to the south by the Iringa Region, to the southwest by the Mbeya Region and to the west by the Itigi District.

[1] According to the 2022 Tanzania National Census, the population of the Manyoni District was 279,069.

[4] Paved trunk road T3 from Morogoro to the Rwanda border passes through the district.

As of 2012, Manyoni District was administratively divided into 30 wards.