Manzanola is a Statutory Town in Otero County, Colorado, United States.

[10] According to the United States Census Bureau, the town has a total area of 0.3 square miles (0.78 km2), all of it land.

As of the census[11] of 2000, there were 525 people, 189 households, and 120 families residing in the town.

There were 209 housing units at an average density of 803.4 per square mile (310.2/km2).

31.2% of all households were made up of individuals, and 16.9% had someone living alone who was 65 years of age or older.