Mao Muzhi, Yuan Zhen, Jiang Bin (江虨) and Zhu Dao (朱燾) joined forces and put down Gan Zan's rebellion.
After Huan Wen was badly defeated at Fangtou, Husheng was appointed Chief Controller of four commanderies, and as Administrator of Eastern Yan.
[5] After Huan Wen deposed Emperor Fei in 371, Mao Husheng was made Chief Controller in Jingzhou north of the Mian River and in Yizheng in Yangzhou.
[6] His brother, Mao Anzhi (毛安之) also played an important role in Huan Wen's government, tasked in defending the palace with his guards.
Mao Husheng camped at Gushu (姑孰; present-day Dangtu County, Anhui) to oppose a potential attack, although the situation was relieved the following year as Xie Xuan drove out Peng Chao.
Mao Husheng's last military activity was in 379, attacking Bazhong to save Weixing (魏興; around present-day Ankang, Shaanxi).