She stood out for her mathematical thinking and work with numbers and made significant contributions to arithmetic, which at the time was considered the exclusive domain of men.

She is one of the few 18th century Spanish women scientists and mathematicians whose work has been preserved, including María Pascuala Caro Sureda.

Maria Andresa Casamayor de La Coma was born on 30 November (Saint Andrew's Day) 1720.

With the death of her father in 1738, and that of the friend and collaborator, Pedro Martínez, in 1739, the young Maria Andresa Casamayor had lost her main support.

Maria Andresa never married or entered a religious order, as expected from women in the Aragonese society of that time.