María Eugenia began her career in 1995 in Petardos and Polémica en el Bar with Gerardo Sofovich; later she performed as a stewardess in the telenovela Amor Latino.
On stage, she has participated in successful seasons with Antonio Gasalla, Nito Artaza, Zulma Faiad, El Negro Alvarez and Tristán, and has acted in theatre productions produced by Gerardo Sofovich such as Soltero y con Dos Viudas (along with Iliana Calabró and Ana Acosta) and Petardos del Humor in Villa Carlos Paz and in Avenida Corrientes, Buenos Aires with Jorge Corona.
In 2008, she starred in the musical comedy El Show de las Divorciadas and in the summer of 2008-2009, she was first vedette with Silvina Luna in Vedettísima, headed by Carmen Barbieri.
In early 2009, she was on the cover of Playboy magazine and participated in El Musical de tus Sueños, and in 2011 she was in Bailando 2011.
On September 29, 2006, she married Marcelo Salinas in the halls of the Sociedad Rural Argentina.