While still attending school, she was selected to star in the film Una novia para David, a script by Senel Paz directed by Orlando Rojas.

[4] In 1996, she moved to Spain, where she appeared on television series such as Javier ya no vive solo [es], Policías, and Aída.

[1][6] In addition, from 2003 to 2006, she participated in the staging of Real Women Have Curves with the Basque company Ados Teatroa, touring throughout Spain, and with two seasons in Madrid and Barcelona.

[2] Her career got a major boost when she was cast in the popular prison drama Locked Up, playing Sole, one of the main inmates.

[1][2] María Isabel Díaz Lago was named Best Actress in a Feature Film at the 2013 Miami Life Awards for Neuralgia.