She began her political career in the Radical Civic Union (UCR) from 1982 until the Alliance appointed Lopez Murphy as minister, and from 2003 to the present in Espacio Abierto, that joined the Front for Victory in the 2009 election.

In the Alliance government she collaborated with Rodolfo Terragno in the Cabinet Office of Ministers, and later was President of the Tripartite Commission of Opportunity Equality and worked with the Ministry of Labor.

The Lubertino administration was characterized by making visible the issue of discrimination in Argentine society in its full dimensions, through growth of the institute's services and active interaction with the media.

The Network addresses discrimination on the basis of gender, disability, racial or ethnic origin, nationality, religious beliefs, sexual identity, age, physical appearance, social status, and any other personal situation or characteristic.

In late 2006, INADI created the Award for Good Anti-Discrimination Practices, to distinguish people and institutions from different disciplines that stood out during each year in the development of actions against discrimination.

She warned that "the body has ceased to have a public presence and is cutting back and retreating," referring to an order by INADI president Javier Buján to close offices of that organization in the interior of the country.

[14] She created Espacio Abierto (Open Space), an organization identified with the democratic left, focusing on human rights, environmental sustainability, equitable distribution of wealth, and social integration and inclusion.

[16] She is also honorary president of the Citizen Association for Human Rights, an entity that works actively for the environment, parity between women and men, and against all types of discrimination and violence.

In the 2013 elections for the Buenos Aires City Legislature, Lubertino – who ended her term as legislator in December – was ranked 15th on the Front for Victory list,[17] and did not renew her seat.

[19] She presented a bill to institutionalize the Observatory, guarantee the labor quota for this population sector, and make registered work compatible with the retirement or non-contributory pension.

[20] Lubertino filed a criminal complaint against the city's Culture Minister Hernán Lombardi in 2013 for having authorized the repurposing of the Bar Notable Richmond, where a local sportswear store began operating.

[22] In 2016, as a result of a tragedy at the Time Warp Festival in Costa Salguero, where five young people died due to drug use, she recounted the irregular situation of the area and denounced the complicity of PRO officials from the City and the Province.