She was born in Sevilla and a member of a clerical family: her brother was a priest, and her sister was a nun.
In 1779, her confessor confessed to the Inquisition to release his guilt over their sexual relationship.
Before the tribunal, she stated that she had been blessed with special relations to heaven since the age of four: she claimed to have had intercourse with the Virgin Mary, that she had been married to Jesus in heaven with St. Joseph and St. Augustin as witnesses, that she had liberated millions of souls from purgatory, and presented the molinist view that sin ceased to be sin when God wills it.
During the investigation, several scholars were called to persuade her to confess her regret and submit.
She refused to regret, and stated that God had revealed to her that she should die a martyr.