María del Rosario Guerra de La Espriella (15 October 1961) is a Colombian economist, professor and politician who has served as Senator since 2014.

She was elected under a newly created political party, the Democratic Center, which is led by former Colombian President Alvaro Uribe.

Guerra had previously held roles as Vice Chancellor of Del Rosario University and also served as Director of the Administrative Department of Science, Technology and Innovation - Colciencias.

In March 2014, she was elected Senator of the Republic for the period 2014–2018 under the Democratic Center, a political movement created and led by Uribe.

[4] In March 2017, Guerra launched a bid for her party's nomination for the 2018 presidential election,[5] but withdrew her name in November.