The station is located at 125 West 225th Street,[3] two blocks west of the Broadway Bridge on the north side of the Harlem River, near the New York City Subway's Marble Hill–225th Street station (which serves the 1 train).

The Marble Hill station is frequently used by commuters going to and from the Manhattan neighborhoods of the Upper West Side, Washington Heights, Hudson Heights and Inwood; about a third of the station's daily ridership disembarks at Marble Hill to transfer to the subway.

[7] Between 1905 and 1906 the New York Central and Hudson River Railroad realigned the tracks along the north coast of the canal and built Marble Hill station on the east side of the Broadway Bridge.

The station has one narrow, 4-car-long high-level island platform accessible by enclosed stairway from West 225th Street.

However, the current location west of Broadway is closer to the residential section of Marble Hill and the downtown platform of the subway.