[1] The graver course is one form of malignant multiple sclerosis, with patients reaching a significant level of disability in less than five years from their first symptoms, often in a matter of months.

[7] If Marburg disease occurs in the form of a single large lesion, it can be radiologically indistinguishable from a brain tumor or abscess.

[10] Recent evidence shows that Marburg's presents a heterogeneous response to medication, as does standard MS.[11] Historically, acute MS was a fatal disease, with death occurring within a year of onset, often secondary to extensive brainstem demyelination.

Patients that satisfy criteria for MS will be treated with immunomodulatory therapies, often favoring high efficacy monoclonal antibodies.

Marburg variant of MS is an acute fulminant demyelinating process which in most cases progresses inexorably to death within 1–2 years.