He played on the Von Nida Tour in 2006, winning two tournaments and topping the order of merit.

He won his maiden title on the Nationwide Tour in 2008 at the WNB Golf Classic by a record-equaling (with Chris Smith) eleven shots.

At the 2013 Masters Tournament, Leishman was the co-leader after the opening round, alongside Sergio García, as he shot a six under total of 66.

[4] On 19 March 2017, Leishman won his second PGA Tour event, the Arnold Palmer Invitational.

On 14 October 2018, Leishman shot a 7-under 65 in the final round to win the CIMB Classic by five strokes and equal Justin Thomas' tournament record of 26-under-par in 2015 on the TPC Kuala Lumpur West course.

In December 2019, Leishman played on the International team at the 2019 Presidents Cup at Royal Melbourne Golf Club in Australia.

Leishman shot a final round 65 to come from behind and defeat Jon Rahm by one stroke.

[9] On 31 March 2015, Audrey admitted herself to hospital suffering from acute respiratory distress syndrome.

He and his wife created the Begin Again Foundation which aids families who need assistance with medical expenses.

1Cancelled due to COVID-19 pandemic QF, R16, R32, R64 = Round in which player lost in match play NT = No tournament "T" = Tied Note that the Championship and Invitational were discontinued from 2022.