[1] He is most notable as the director of critically acclaimed African documentaries such as Tchindas, Peixos d'aigua dolça and The Writer from a Country Without Bookstores.

[4] In 2014, Serena published Un-African love?, which compiling queer voices from 15 African countries.

In the same year, Serena wrote and directed the critically acclaimed film Tchindas, co-directed with Pablo García Pérez de Lara.

The film later won Outfest's Grand Jury Award for Excellence in Filmmaking.

In 2018, he directed the film Peixos d'aigua dolça and then The Writer from a Country Without Bookstores in 2019.