The FA WSL was in the middle of a switch to the traditional autumn-to-spring calendar and, as a result, Skinner's first campaign was the shortened 8-game Spring Series from February–May 2017 where Birmingham finished 7th.

[5] On 14 January 2019, Skinner was announced as head coach of Orlando Pride, a team he called "one of the biggest clubs in the world.

[7] With the 2020 season disrupted by the COVID-19 pandemic, Orlando Pride saw their schedule reduced to four Fall Series matches.

The team failed to win any of them but notably ended the series in dramatic fashion with a second-half comeback from three goals down to tie with North Carolina Courage.

[10][11] On 29 July 2021, Skinner returned to the FA WSL to become the second head coach of Manchester United, taking over from Casey Stoney following her resignation in May 2021.

[16] Skinner is in a long-term relationship with former England international defender Laura Bassett having met while both coaching for Birmingham's U-14s team.