Marcantonio Colonna (16 August 1724 – 4 December 1793) was an Italian Catholic cardinal.

Born in Rome on 16 August 1724, Colonna was made Cardinal-Deacon of Santa Maria in Aquiro by Pope Clement XIII on 19 November 1759.

He was appointed Titular Archbishop of Corinthus and Cardinal-Priest of Santa Maria della Pace by Pope Clement XIII on 19 April 1762.

Pope Clement XIII acted as his consecrator while Cardinal Gian Francesco Albani (grand-nephew of Pope Clement XI) and Cardinal Henry Benedict Stuart acted as co-consecrators.

On 25 June 1784, Colonna was made Cardinal-Priest of San Lorenzo in Lucina by Pope Clement XIV and on 20 September 1784, he was appointed Cardinal-Bishop of Palestrina.