It is also referred to as Santa Maria della Visitazione, notably by Pope Urban VI in 1389.

[1] In 1540 Pope Paul III granted the church to the Confraternity of Orphans, and it was restored in 1588.

The most important work of art in the church is a 14th-century painting, in the apse, of the Madonna and Child with St Stephen, attributed to the school of Pietro Cavallini.

This painting and the funeral lapidary monuments in the vestibule are from the medieval church of Santo Stefano del Trullo, destroyed during the pontificate of Pope Alexander VII (1655–1667).

The facade was completed by 1774 by Pietro Camporese the Elder, based on designs of Giovanni Francesco Braccioli.