Marche-en-Famenne (French pronunciation: [maʁʃ ɑ̃ famɛn] ⓘ; Walloon: Måtche-el-Fåmene [mɑːtʃ ɛl fɑːmɛn]; literally "Marche in Famenne") is a city and municipality of Wallonia located in the Belgian province of Luxembourg.

It was ideally located, on the main road between Namur and Luxembourg City, and quickly evolved into a town, which obtained its charter in the 13th century.

At the end of the century, in true medieval fashion, it acquired a complete system of defensive walls, with two gates, a series of watchtowers, and a keep.

In the aftermath of the Pacification of Ghent, Don John of Austria, Philip II's half brother, granted the Perpetual Edict, which was signed in the city in February 1577.

Fighting occurred in and around Marche in December 1944 as part of the Battle of the Bulge, the last major German offensive in West during World War II.