Born in West Kingston, Jamaica, Griffiths started her career in 1964, performing on stage with Byron Lee and the Dragonaires at the behest of Phillip James of The Blues Busters, who had heard her singing in her home neighbourhood.

[3][4] Her performance was sufficiently impressive that the following day Ronnie Nasralla and Clement Dodd both offered her recording contracts.

[1] She continued to record as a solo artist throughout the 1970s, working with producers such as Sonia Pottinger, and Joseph Hoo Kim.

[3] Griffiths was featured on the album True Love by Toots and the Maytals, which won the Grammy Award in 2004 for Best Reggae Album, and showcased many notable musicians including Willie Nelson, Eric Clapton, Jeff Beck, Trey Anastasio, Gwen Stefani / No Doubt, Ben Harper, Bonnie Raitt, Manu Chao, The Roots, Ryan Adams, Keith Richards, Toots Hibbert, Paul Douglas, Jackie Jackson, Ken Boothe, and The Skatalites.

[3] In August 2014, it was announced that Griffiths would receive the Jamaican Order of Distinction (Commander class) in October that year.